Combined normal donor and CLL: Single tube ZAP-70 analysis

The Biological Relevance of ZAP-70 in CLL

NEOPLASIA CD38 and ZAP-70 are functionally linked and mark CLL cells with high migratory potential

1Department of Genetics, Biology and Biochemistry, University of Torino Medical School, Turin, Italy; 2Research Center for Experimental Medicine (CeRMS), University of Torino Medical School, Turin, Italy; 3Department of Medicine and Experimental Oncology, University of Torino Medical School, Turin, Italy; 4Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Fondazione G. Pascale, Naples...

CD38 and ZAP-70 are functionally linked and mark CLL cells with high migratory potential.

Our interest in chronic lymphocytic leukemia (CLL) derives primarily from the exploitation of human diseases as strategic models for defining the in vivo biological roles of CD38. Using this model, we showed that CD38 triggers robust proliferation/survival signals modulated through the interactions with the CD31 ligand expressed by nurse-like cells and by the stromal/endothelial components. By ...

Clinical Significance of ZAP-70 Protein Expression in B-cell Chronic Lymphocytic Leukemia Short title: ZAP-70 and prognosis in B-CLL

Prepublished online April 6, 2006; Amadori Gattei, Paolo de Fabritiis, Maria Cantonetti, Francesco Lo Coco, Domenico Del Principe and Sergio Ottaviani, Paola Panetta, Antonio Bruno, Riccardo Bomben, Giovanna Suppo, Massimo Degan, Valter Licia Antonella Zucchetto, Rita Marini, Pasquale Niscola, Maria Antonietta Irno Consalvo, Carla Mazzone, Maria Ilaria Del Principe, Giovanni Del Poeta, Francesc...

ZAP-70 expression in B-cell hematologic malignancy is not limited to CLL/SLL.

ZAP-70 is a tyrosine kinase expressed in normal T cells and NK cells. Expression of ZAP-70 has been associated with poor prognosis in B-cell chronic lymphocytic leukemia and might be a surrogate marker for immunoglobin heavy chain (IGH) mutational status in that disease. Little is known about ZAP-70 expression in other hematologic malignant neoplasms. We examined 446 specimens representing a ra...